Rx Chicken and Oysters

Wilmington, NC · Seafood restaurant

Rating
4.6/5
★★★★★ 4.6
Reviews
20
Rank in Wilmington
#241
of 753 restaurants
City Percentile
62%
rating percentile
Address
Rx Chicken and Oysters, 421 Castle St, Wilmington, NC 28401
Phone
(910) 399-3080
Website
www.rxwilmington.com
Status
Closed · Opens 5 PM

Rx Chicken and Oysters is a restaurant located in Wilmington, NC. It is one of 753 restaurants listed in Wilmington. Its 4.6-star rating is above the Wilmington city average of 4.3 stars. There are 10 photos associated with this location.

About Rx Chicken and Oysters

Rx Chicken and Oysters is a neighborhood farm and sea to table restaurant farming our own “Lucy Bea” oysters and catching/spearing our own fish, including the invasive but delicious lionfish. We serve exclusively N.C. seafood and focus on local... More

Hours

Saturday5 PM–9 PM

Customer Reviews

★★★★★ 5.0 Matt Hempson · Dec 2025

This was my first visit to Rx Chicken and Oysters since they reopened with a more casual dining concept. While the original Rx leaned toward a fine-dining experience, the new approach feels relaxed and inviting without sacrificing quality. The atmosphere was warm and welcoming, the food was outstanding across the board, and our waitress was truly exceptional. I would highly recommend the Lucy Bea oysters and the blueberry hand pie for dessert. We had a wonderful time and will absolutely be back.

★★★★★ 5.0 Rob Longo · Nov 2025

We took some friends to RX Chicken & Oysters last night. Our first time there as well as theirs. Lily was our waitress and was excellent. She made recommendations and told us her favorites. We have Oysters Rockefeller, Fried Oysters, Crab Cakes, Blueberry Hand Pie and Dark Chocolate Brownie. The food was excellent. We will be back!

★★★★★ 5.0 Carly Dodds · Sep 2025

Hiddem gem in Wilmington! As a pharmacist, I was initially intrigued since this restaurant used to be a pharmacy (although the decor & inside is not pharmacy themed) but we decided to try it based on the food options. Our waitress was friendly & knowledgeable. We aren't big seafood eaters so she took the time to explain the catch-of-the-day options. We had never heard of lionfish (see pictures for a sculpture of this spiky fish) but my husband decided to try it. And it ended up being his favorite meal of the whole trip! It's a little pricey, but you can taste the quality & freshness of the food. Everything was delicious & well-prepared. Highly recommend trying a dessert served with their soft-serve ice cream. Just a few blocks from downtown, its hidden on a residential street but definitel

★★★★☆ 4.0 Pablo Ohulahan · Feb 2026

Deviled eggs had too much filling and mustard taste. Oysters were over-seasoned with spinach and not all the way full. Fish fresh catch was amazing. Chicken was ok nothing special.

★★★★★ 5.0 Latisha Jeffers · Jun 2025

After a dud of a seafood meal the previous night, we were looking for a redemption meal. We found it at Rx Chicken & Oysters! The food is sustainable, locally sourced, and outstanding! Many places tout the “sea to table,” but few actually give you food that truly tastes like It. Rx wrote the book on it! We had the spiny lobster tail hush puppies, skillet corn bread, grouper with spiny lobster tail rice and heirloom tomato reduction, grunt with grits, seasonal vegetables and citrus and herb butter, brownie with soft serve, and blueberry cobbler. Everything was fresh and cooked perfectly! The fish had amazing flavor and the crust was just right. The tomato reduction had incredible flavor! The grits were delicious - a tasty nod to southern culture and paired with the fish nicely. Start to fin

Accessibility & Amenities

✓ Wheelchair Accessible Entrance ✓ Wheelchair Accessible Parking Lot ✓ Wheelchair Accessible Restroom ✓ Wheelchair Accessible Seating

Services

Seafood restaurantFried chicken takeawayNew American restaurantOyster bar restaurantSouthern restaurant (US)

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This listing is informational. Contact the business directly to verify credentials, services, and availability.