La Jaliscience Mexican Restaurant & Groceries

Defiance, OH · Mexican restaurant

Rating
4.6/5
★★★★★ 4.6
Reviews
20
Rank in Defiance
#12
of 68 restaurants
City Percentile
72%
rating percentile
Address
La Jaliscience Mexican Restaurant & Groceries, 531 E 2nd St, Defiance, OH 43512
Phone
(419) 782-1612
Website
lajaliscience.com
Status
Closed · Opens 9 AM Sat

La Jaliscience Mexican Restaurant & Groceries is a restaurant located in Defiance, OH. It is one of 68 restaurants listed in Defiance. Its 4.6-star rating is above the Defiance city average of 4.2 stars. It ranks #12 of 68 restaurants in Defiance. There are 10 photos associated with this location.

About La Jaliscience Mexican Restaurant & Groceries

Order Online. Here at La Jaliscience - Defiance you'll experience delicious Mexican cuisine. Try our mouth-watering dishes, carefully prepared with fresh ingredients! At La Jaliscience, our recipe for success is simple – Great food & care makes... More

Hours

Friday9 AM–10 PM

Customer Reviews

★★★★★ 5.0 Christopher Burnett · Feb 2026

La Jaliscience is my favorite restaurant in Defiance. Not just Mexican restaurant, any restaurant. I try to order something new from the menu often and everything I've had there is great! The birria burrito and pollo poblano are two of my favorite dishes! The staff is always very friendly and the drinks are delicious! On Wednesdays and weekends, there is a lady there who makes the best guacamole I've ever eaten! As noted by others, the parking can be a bit wonky and sometimes it's better to park at the bank across the street and walk over. The grocery side is great too for finding spices and other essentials for home.

★★★★★ 5.0 embMNdoc · Jan 2026

We were traveling through northwest Ohio over the holidays trying to avoid tolls and chain chow. La Jaliscience appeared right along our route on googly. I cannot say enough how happy I was. The tamales are homemade and remind you of family. Sauces are made from scratch and tended without hurry. These folks love preparing food and it shows. Heads up: La Jaliscience is a grocery and restaurant in an unassuming storefront on the corner of E. 2nd St and Douglas St in Defiance, OH. It's a location and building that was probably a convenience store or service station in a previous life, so pay attention so you don't miss it. Both the grocery and the restaurant are clean and inviting, and they are separated in such a way that any activity from the grocery doesn't intrude on your meal.

★★★★☆ 4.0 Rick Gonzalez · Oct 2025

This neighborhood market, grocery store, resto and family owners have been around Defiance for a long time. My first encounter with this local gem was over twenty years ago on my first visit to this Ohio town, and it’s still around with improvements, enhancements and is still great overall! A terrific family run business. From its jam-packed with a wide array of dry and can goods on grocery shelves, great meats, extensive local baked goods, and a much renovated and expanded restaurant and really nice Mexican-style bar! If you’re in town and are in the mood for an ice-cold Dox Equis and/or Jalisco style Mexican cuisine, this the place for you! Their goodies run the gamut from an incredible Pozole to Grilled Chicken delights, to delectable Burritos to mouthwatering tacos, some terrific, refr

★★★★★ 5.0 Melinda Dennis · Feb 2026

Best Mexican I have had since being in college in San Antonio. Fresh ingredients and delicious. The margarita was amazing as well! Great prices as well.

★★★★★ 5.0 Tessa Gutierrez · Dec 2025

Such friendly and quick service! It was my first time dining in, and the atmosphere was warm and community.

Accessibility & Amenities

✓ Wheelchair Accessible Entrance ✓ Wheelchair Accessible Parking Lot ✓ Wheelchair Accessible Restroom ✓ Wheelchair Accessible Seating

Services

Mexican restaurantMexican goods storeRestaurantTaco restaurant

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This listing is informational. Contact the business directly to verify credentials, services, and availability.